Placental miRNA expression in association with in utero particulate air pollution exposure
نویسندگان
چکیده
Background and aims Particulate matter exposure during in utero life may entail adverse health outcomes later in life. Epidemiological studies in adults have linked air pollution’s adverse effects to alterations in gene expression profiles, which can be regulated by epigenetic mechanisms, including microRNAs (miRNAs). MiRNAs have been implicated in diverse biological processes. We investigate the potential influence of air pollution exposure in early life on placental miRNA expression.
منابع مشابه
Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach
Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. Air pollution's adverse effects are known to alter gene expression profiles, which can be regulated by microRNAs (miRNAs). We investigate the potential influence of air pollution exposure in prenatal life on placental miRNA expression. Within the framework of the ENVIRONAGE birth cohort, we m...
متن کاملPlacental nitrosative stress and in utero exposure to particulate matter
Background and aims A wide variety of adverse health effects on both fetuses and neonates have been ascribed to particulate matter (PM) air pollution. Recent evidence suggests that PM exposure results in increased oxidative and nitrosative stress. In the ENVIRONAGE birth cohort, we investigated the association of placental 3-nitrotyrosine (3-NT) with PM exposure during various time windows of p...
متن کاملPlacental DNA methylation as a proxy for fetal neurodevelopment and sex-specific associations with in utero particulate air pollution
Background and aims Exposure to particulate matter (PM) air pollution during pregnancy may affect human fetal development. Epigenetic mechanisms are believed to play an essential role in the developmental changes during early life. Within the ENVIRONAGE birth cohort, we investigated whether in utero exposure to PM is associated with differences in placental DNA methylation of genes involved in ...
متن کاملPmn-18: The Effect of Ambient Air Pollution on Infertility
Development disorders may be arisen from the unavoidable maternal exposure to particulate air pollution during the prenatal life that can be affected not only periconceptional period but also postnatal life. A kind of chemical material categorized as air pollutants are present in the urine, blood and semen of exposed men and may decline sperm count and affect sperm quality. Environment toxic ca...
متن کاملIn Utero Fine Particle Air Pollution and Placental Expression of Genes in the Brain-Derived Neurotrophic Factor Signaling Pathway: An ENVIRONAGE Birth Cohort Study
BACKGROUND Developmental processes in the placenta and the fetal brain are shaped by the same biological signals. Recent evidence suggests that adaptive responses of the placenta to the maternal environment may influence central nervous system development. OBJECTIVES We studied the association between in utero exposure to fine particle air pollution with a diameter ≤ 2.5 μm (PM2.5) and placen...
متن کامل